293d

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(New page: 200px<br /><applet load="293d" size="350" color="white" frame="true" align="right" spinBox="true" caption="293d, resolution 1.000&Aring;" /> '''INTERACTION BETWEEN...)
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==Overview==
==Overview==
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This paper deals with the crystal structure of d(CG)3-spermidine complex., The DNA fragment, d(CG)3, was crystallized with, N-(2-amino-propyl)-1,4-diamino-butane, PA(34), spermidine. The results of, its X-ray crystallographic analysis showed many intermolecular contacts, between d(CG)3 and spermidine, but the binding mode of spermidine to the, d(CG)3 molecule is different from that of the d(CG)3 and, N-(2-amino-ethyl)-1,4-diamino-butane [PA(24)] complex: a spermidine, molecule bound to the d(CG)3 and its symmetrically related neighboring, d(CG)3 molecules through the water molecules with hydrogen bonds, while, one PA(24) molecule connected directly to one d(CG)3 molecule, but not to, its neighboring d(CG)3 molecule. In the crystal, the d(CG)3 molecule was, the left-handed Z-form, and three magnesium cations and a sodium cation, were observed around the d(CG)3 moiety with different binding modes from, the case of the d(CG)3-PA(24) complex.
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This paper deals with the crystal structure of d(CG)3-spermidine complex. The DNA fragment, d(CG)3, was crystallized with N-(2-amino-propyl)-1,4-diamino-butane, PA(34), spermidine. The results of its X-ray crystallographic analysis showed many intermolecular contacts between d(CG)3 and spermidine, but the binding mode of spermidine to the d(CG)3 molecule is different from that of the d(CG)3 and N-(2-amino-ethyl)-1,4-diamino-butane [PA(24)] complex: a spermidine molecule bound to the d(CG)3 and its symmetrically related neighboring d(CG)3 molecules through the water molecules with hydrogen bonds, while one PA(24) molecule connected directly to one d(CG)3 molecule, but not to its neighboring d(CG)3 molecule. In the crystal, the d(CG)3 molecule was the left-handed Z-form, and three magnesium cations and a sodium cation were observed around the d(CG)3 moiety with different binding modes from the case of the d(CG)3-PA(24) complex.
==About this Structure==
==About this Structure==
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Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex., Ohishi H, Nakanishi I, Inubushi K, van der Marel G, van Boom JH, Rich A, Wang AH, Hakoshima T, Tomita K, FEBS Lett. 1996 Aug 5;391(1-2):153-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8706905 8706905]
Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex., Ohishi H, Nakanishi I, Inubushi K, van der Marel G, van Boom JH, Rich A, Wang AH, Hakoshima T, Tomita K, FEBS Lett. 1996 Aug 5;391(1-2):153-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8706905 8706905]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Boom, J.H.Van.]]
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[[Category: Boom, J H.Van.]]
[[Category: Hakoshima, T.]]
[[Category: Hakoshima, T.]]
[[Category: Inubushi, K.]]
[[Category: Inubushi, K.]]
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[[Category: Marel, G.A.Van.Der.]]
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[[Category: Marel, G A.Van Der.]]
[[Category: Nakanishi, I.]]
[[Category: Nakanishi, I.]]
[[Category: Ohishi, H.]]
[[Category: Ohishi, H.]]
[[Category: Rich, A.]]
[[Category: Rich, A.]]
[[Category: Tomita, K.]]
[[Category: Tomita, K.]]
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[[Category: Wang, A.H.J.]]
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[[Category: Wang, A H.J.]]
[[Category: MG]]
[[Category: MG]]
[[Category: NA]]
[[Category: NA]]
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[[Category: z-dna]]
[[Category: z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 17:51:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:22:15 2008''

Revision as of 14:22, 21 February 2008

Image:293d.gif

293d, resolution 1.000Å

Drag the structure with the mouse to rotate

INTERACTION BETWEEN THE LEFT-HANDED Z-DNA AND POLYAMINE-2: THE CRYSTAL STRUCTURE OF THE D(CG)3 AND SPERMIDINE COMPLEX

Overview

This paper deals with the crystal structure of d(CG)3-spermidine complex. The DNA fragment, d(CG)3, was crystallized with N-(2-amino-propyl)-1,4-diamino-butane, PA(34), spermidine. The results of its X-ray crystallographic analysis showed many intermolecular contacts between d(CG)3 and spermidine, but the binding mode of spermidine to the d(CG)3 molecule is different from that of the d(CG)3 and N-(2-amino-ethyl)-1,4-diamino-butane [PA(24)] complex: a spermidine molecule bound to the d(CG)3 and its symmetrically related neighboring d(CG)3 molecules through the water molecules with hydrogen bonds, while one PA(24) molecule connected directly to one d(CG)3 molecule, but not to its neighboring d(CG)3 molecule. In the crystal, the d(CG)3 molecule was the left-handed Z-form, and three magnesium cations and a sodium cation were observed around the d(CG)3 moiety with different binding modes from the case of the d(CG)3-PA(24) complex.

About this Structure

293D is a Protein complex structure of sequences from [1] with , and as ligands. Full crystallographic information is available from OCA.

Reference

Interaction between the left-handed Z-DNA and polyamine-2. The crystal structure of the d(CG)3 and spermidine complex., Ohishi H, Nakanishi I, Inubushi K, van der Marel G, van Boom JH, Rich A, Wang AH, Hakoshima T, Tomita K, FEBS Lett. 1996 Aug 5;391(1-2):153-6. PMID:8706905

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