Villin
From Proteopedia
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== 3D Structures of Villin == | == 3D Structures of Villin == | ||
| - | ''Update | + | ''Update February 2013'' |
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=== Villin === | === Villin === | ||
| - | [[3fg7]] – hVIL gelsolin domains 4-6<br /> | + | [[3fg7]] – hVIL gelsolin domains 4-6<br /> |
| + | [[2llf]] - hVIL gelsolin-like domain 6 - NMR<br /> | ||
[[1unc]] – hVIL headpiece<br /> | [[1unc]] – hVIL headpiece<br /> | ||
[[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br /> | [[3iur]] - hVIL headpiece H2H3 helices+prolyl endopeptidase – ''Aeromonas punctata''<br /> | ||
Revision as of 11:14, 14 February 2013
Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n).
3D Structures of Villin
Update February 2013
Supervillin
2k6m, 2k6n – hSVIL headpiece– human – NMR
Villin
3fg7 – hVIL gelsolin domains 4-6
2llf - hVIL gelsolin-like domain 6 - NMR
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL headpiece (mutant)
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic
Advillin
1und – hAVIL headpiece
References
- ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, David Canner, Jaime Prilusky, Joel L. Sussman
