2a0t
From Proteopedia
(New page: 200px<br /><applet load="2a0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a0t" /> '''NMR structure of the FHA1 domain of Rad53 in...) |
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| - | [[Image:2a0t.gif|left|200px]]<br /><applet load="2a0t" size=" | + | [[Image:2a0t.gif|left|200px]]<br /><applet load="2a0t" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2a0t" /> | caption="2a0t" /> | ||
'''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1'''<br /> | '''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2A0T is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 2A0T is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0T OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Chang, C | + | [[Category: Chang, C F.]] |
[[Category: Heierhorst, J.]] | [[Category: Heierhorst, J.]] | ||
[[Category: Mahajan, A.]] | [[Category: Mahajan, A.]] | ||
| - | [[Category: Pike, B | + | [[Category: Pike, B L.]] |
| - | [[Category: Tsai, M | + | [[Category: Tsai, M D.]] |
[[Category: Yuan, C.]] | [[Category: Yuan, C.]] | ||
[[Category: fha domain. rad53]] | [[Category: fha domain. rad53]] | ||
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[[Category: phosphothreonine]] | [[Category: phosphothreonine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:22:34 2008'' |
Revision as of 14:22, 21 February 2008
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NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1
Overview
Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.
About this Structure
2A0T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:16231900
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