2a2j
From Proteopedia
(New page: 200px<br /><applet load="2a2j" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a2j, resolution 2.50Å" /> '''Crystal structure of...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2a2j.gif|left|200px]]<br /><applet load="2a2j" size=" | + | [[Image:2a2j.gif|left|200px]]<br /><applet load="2a2j" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2a2j, resolution 2.50Å" /> | caption="2a2j, resolution 2.50Å" /> | ||
'''Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis'''<br /> | '''Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of Rv2607, a putative pyridoxine | + | The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family. |
==About this Structure== | ==About this Structure== | ||
| - | 2A2J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] Full crystallographic information is available from [http:// | + | 2A2J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Pyridoxal 5'-phosphate synthase]] | [[Category: Pyridoxal 5'-phosphate synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Hung, L | + | [[Category: Hung, L W.]] |
| - | [[Category: Kim, C | + | [[Category: Kim, C Y.]] |
| - | [[Category: Kim, S | + | [[Category: Kim, S I.]] |
| - | [[Category: Lekin, T | + | [[Category: Lekin, T P.]] |
| - | [[Category: Pedelacq, J | + | [[Category: Pedelacq, J D.]] |
| - | [[Category: Rho, B | + | [[Category: Rho, B S.]] |
[[Category: Rupp, B.]] | [[Category: Rupp, B.]] | ||
| - | [[Category: Segelke, B | + | [[Category: Segelke, B W.]] |
| - | [[Category: Terwilliger, T | + | [[Category: Terwilliger, T C.]] |
| - | [[Category: Waldo, G | + | [[Category: Waldo, G S.]] |
| - | [[Category: XMTB, Mycobacterium | + | [[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]] |
[[Category: beta barrel]] | [[Category: beta barrel]] | ||
[[Category: mycobacterium tuberculosis structural proteomics project]] | [[Category: mycobacterium tuberculosis structural proteomics project]] | ||
| Line 30: | Line 30: | ||
[[Category: xmtb]] | [[Category: xmtb]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:01 2008'' |
Revision as of 14:23, 21 February 2008
|
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis
Overview
The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family.
About this Structure
2A2J is a Single protein structure of sequence from Mycobacterium tuberculosis. Active as Pyridoxal 5'-phosphate synthase, with EC number 1.4.3.5 Full crystallographic information is available from OCA.
Reference
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis., Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC, Proteins. 2006 Mar 15;62(3):563-9. PMID:16374842
Page seeded by OCA on Thu Feb 21 16:23:01 2008
Categories: Mycobacterium tuberculosis | Pyridoxal 5'-phosphate synthase | Single protein | Hung, L W. | Kim, C Y. | Kim, S I. | Lekin, T P. | Pedelacq, J D. | Rho, B S. | Rupp, B. | Segelke, B W. | Terwilliger, T C. | Waldo, G S. | XMTB, Mycobacterium Tuberculosis Structural Proteomics Project. | Beta barrel | Mycobacterium tuberculosis structural proteomics project | Structural genomics | Xmtb
