2a4g
From Proteopedia
(New page: 200px<br /><applet load="2a4g" size="350" color="white" frame="true" align="right" spinBox="true" caption="2a4g, resolution 2.50Å" /> '''Hepatitis C Protease...) |
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==Overview== | ==Overview== | ||
| - | We have discovered that introduction of appropriate amino acid derivatives | + | We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P'2 moiety. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Arasappan, A.]] | [[Category: Arasappan, A.]] | ||
[[Category: Bennett, F.]] | [[Category: Bennett, F.]] | ||
| - | [[Category: Bogen, S | + | [[Category: Bogen, S L.]] |
[[Category: Butkiewicz, N.]] | [[Category: Butkiewicz, N.]] | ||
| - | [[Category: Chan, T | + | [[Category: Chan, T Y.]] |
[[Category: Chen, K.]] | [[Category: Chen, K.]] | ||
| - | [[Category: Ganguly, A | + | [[Category: Ganguly, A K.]] |
[[Category: Girijavallabhan, V.]] | [[Category: Girijavallabhan, V.]] | ||
[[Category: Gu, H.]] | [[Category: Gu, H.]] | ||
| Line 28: | Line 28: | ||
[[Category: Levy, O.]] | [[Category: Levy, O.]] | ||
[[Category: Lim-Wilby, M.]] | [[Category: Lim-Wilby, M.]] | ||
| - | [[Category: Liu, Y | + | [[Category: Liu, Y T.]] |
| - | [[Category: Lovey, R | + | [[Category: Lovey, R G.]] |
[[Category: Malcolm, B.]] | [[Category: Malcolm, B.]] | ||
[[Category: Marten, B.]] | [[Category: Marten, B.]] | ||
[[Category: Mckittrick, B.]] | [[Category: Mckittrick, B.]] | ||
| - | [[Category: Njoroge, F | + | [[Category: Njoroge, F G.]] |
[[Category: Parekh, T.]] | [[Category: Parekh, T.]] | ||
[[Category: Pichardo, J.]] | [[Category: Pichardo, J.]] | ||
| - | [[Category: Pike, R | + | [[Category: Pike, R E.]] |
[[Category: Pinto, P.]] | [[Category: Pinto, P.]] | ||
| - | [[Category: Prongay, A | + | [[Category: Prongay, A J.]] |
| - | [[Category: Saksena, A | + | [[Category: Saksena, A K.]] |
[[Category: Santhanam, B.]] | [[Category: Santhanam, B.]] | ||
[[Category: Tamura, S.]] | [[Category: Tamura, S.]] | ||
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[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:30 2008'' |
Revision as of 14:23, 21 February 2008
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Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
Overview
We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to the protease revealed the importance of the P'2 moiety.
About this Structure
2A4G is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.
Reference
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency., Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332
Page seeded by OCA on Thu Feb 21 16:23:30 2008
Categories: Hepatitis c virus | Protein complex | Arasappan, A. | Bennett, F. | Bogen, S L. | Butkiewicz, N. | Chan, T Y. | Chen, K. | Ganguly, A K. | Girijavallabhan, V. | Gu, H. | Hong, L. | Ingram, R. | Jao, E. | Kemp, S. | Levy, O. | Lim-Wilby, M. | Liu, Y T. | Lovey, R G. | Malcolm, B. | Marten, B. | Mckittrick, B. | Njoroge, F G. | Parekh, T. | Pichardo, J. | Pike, R E. | Pinto, P. | Prongay, A J. | Saksena, A K. | Santhanam, B. | Tamura, S. | V., Madison | Vaccaro, H. | Venkatraman, S. | Wang, H. | Yang, X. | Yao, N. | Zhu, Z. | UNH | ZN | Virus/viral protein
