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1jia
From Proteopedia
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[[Category: phospholipase a2]] | [[Category: phospholipase a2]] | ||
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Revision as of 13:35, 30 October 2007
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STRUCTURE OF A BASIC PHOSPHOLIPASE A2 FROM AGKISTRODON HALYS PALLAS AT 2.13A RESOLUTION
Overview
The basic phospholipase A2 isolated from the venom of Agkistrodon halys, Pallas (Agkistrodon blomhoffii Brevicaudus) is a hemolytic toxin and one, of the few PLA2's capable of hydrolyzing the phospholipids of E. coli, membranes in the presence of a bactericidal/permeability-increasing, protein (BPI) of neutrophils. The crystal structure has been determined, and refined at 2.13 A to an R factor of 16.5% (F > 3sigma) with excellent, stereochemistry. A superposition of the two molecules in the asymmetric, unit gives an r. m.s. deviation of 0.326 A for all Calpha atoms. The, refined structure allowed a detailed comparison with other PLA2 species of, known structures. The overall architecture is similar to those of other, PLA2's with a few significant differences. One of which is in the ... [(full description)]
About this Structure
1JIA is a [Single protein] structure of sequence from [Gloydius halys] with CA as [ligand]. Active as [Phospholipase A(2)], with EC number [3.1.1.4]. Structure known Active Sites: ATA and ATB. Full crystallographic information is available from [OCA].
Reference
Structure of a basic phospholipase A2 from Agkistrodon halys Pallas at 2.13 A resolution., Zhao K, Song S, Lin Z, Zhou Y, Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):510-21. PMID:9761847
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