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3g1l

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[[Image:3g1l.png|left|200px]]
[[Image:3g1l.png|left|200px]]
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{{STRUCTURE_3g1l| PDB=3g1l | SCENE= }}
{{STRUCTURE_3g1l| PDB=3g1l | SCENE= }}
===EthR from Mycobacterium tuberculosis in complex with compound BDM14744===
===EthR from Mycobacterium tuberculosis in complex with compound BDM14744===
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{{ABSTRACT_PUBMED_19412174}}
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==Reference==
==Reference==
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<ref group="xtra">PMID:19412174</ref><ref group="xtra">PMID:16243584</ref><ref group="xtra">PMID:15494316</ref><ref group="xtra">PMID:14651620</ref><references group="xtra"/>
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<ref group="xtra">PMID:019412174</ref><ref group="xtra">PMID:016243584</ref><ref group="xtra">PMID:015494316</ref><ref group="xtra">PMID:014651620</ref><references group="xtra"/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Aumercier, M.]]
[[Category: Aumercier, M.]]

Revision as of 14:22, 20 February 2013

Image:3g1l.png

Template:STRUCTURE 3g1l

EthR from Mycobacterium tuberculosis in complex with compound BDM14744

Template:ABSTRACT PUBMED 19412174

About this Structure

3g1l is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Willand N, Dirie B, Carette X, Bifani P, Singhal A, Desroses M, Leroux F, Willery E, Mathys V, Deprez-Poulain R, Delcroix G, Frenois F, Aumercier M, Locht C, Villeret V, Deprez B, Baulard AR. Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat Med. 2009 May;15(5):537-44. Epub 2009 May 3. PMID:19412174 doi:10.1038/nm.1950
  • Frenois F, Baulard AR, Villeret V. Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis. Tuberculosis (Edinb). 2006 Mar;86(2):110-4. Epub 2005 Oct 21. PMID:16243584 doi:10.1016/j.tube.2005.07.005
  • Frenois F, Engohang-Ndong J, Locht C, Baulard AR, Villeret V. Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis. Mol Cell. 2004 Oct 22;16(2):301-7. PMID:15494316 doi:10.1016/j.molcel.2004.09.020
  • Engohang-Ndong J, Baillat D, Aumercier M, Bellefontaine F, Besra GS, Locht C, Baulard AR. EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator. Mol Microbiol. 2004 Jan;51(1):175-88. PMID:14651620

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