1jnq
From Proteopedia
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[[Category: purple lipoxygenase]] | [[Category: purple lipoxygenase]] | ||
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Revision as of 13:36, 30 October 2007
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LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)
Overview
Lipoxygenases (LOXs) are non-heme iron containing enzymes ubiquitous in, nature and participating in the metabolism of the polyunsaturated fatty, acids (PUFA). They are capable of combining their dioxygenase activity, with its co-oxidative activity manifesting itself in biotransformation, reactions catalyzed by LOXs for other than PUFA small molecules. LOXs, involvement in inflammatory diseases and cancer have been well documented., Catechins are the natural flavonoids of known inhibitory activity toward, dioxygenases with a potential to be utilized in disease prevention and, treatment. This work presents results obtained from an X-ray analysis of, (-)-epigallocatechin gallate (EGCG) interacting with soybean, lipoxygenase-3. The 3D structure of the resulting complex reveals the, inhibitor ... [(full description)]
About this Structure
1JNQ is a [Single protein] structure of sequence from [Glycine max] with FE2 and EGT as [ligands]. Active as [Lipoxygenase], with EC number [1.13.11.12]. Structure known Active Site: FE. Full crystallographic information is available from [OCA].
Reference
Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:12964012
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