2aaq
From Proteopedia
(New page: 200px<br /> <applet load="2aaq" size="450" color="white" frame="true" align="right" spinBox="true" caption="2aaq, resolution 2.60Å" /> '''Crystal Structure A...) |
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| - | [[Image:2aaq.gif|left|200px]]<br /> | + | [[Image:2aaq.gif|left|200px]]<br /><applet load="2aaq" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2aaq, resolution 2.60Å" /> | caption="2aaq, resolution 2.60Å" /> | ||
'''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI'''<br /> | '''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI'''<br /> | ||
==Disease== | ==Disease== | ||
| - | Known | + | Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]], Mental retardation, autosomal recessive, 6 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138244 138244]] |
==About this Structure== | ==About this Structure== | ||
| - | 2AAQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4, CL, K, FAD, AUP, AU and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] Full crystallographic information is available from [http:// | + | 2AAQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=AUP:'>AUP</scene>, <scene name='pdbligand=AU:'>AU</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein gold complex]] | [[Category: protein gold complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:25:37 2008'' |
Revision as of 14:25, 21 February 2008
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Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI
Disease
Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[138300], Mental retardation, autosomal recessive, 6 OMIM:[138244]
About this Structure
2AAQ is a Single protein structure of sequence from Homo sapiens with , , , , , and as ligands. Active as Glutathione-disulfide reductase, with EC number 1.8.1.7 Full crystallographic information is available from OCA.
Reference
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases., Urig S, Fritz-Wolf K, Reau R, Herold-Mende C, Toth K, Davioud-Charvet E, Becker K, Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. PMID:16493712
Page seeded by OCA on Thu Feb 21 16:25:37 2008
Categories: Glutathione-disulfide reductase | Homo sapiens | Single protein | Becker, K. | Davioud-Charvet, E. | Fritz-Wolf, K. | Herold-Mende, C. | Reau, R. | Toth, K. | Urig, S. | AU | AUP | CL | FAD | GOL | K | PO4 | Antioxidative system | Disulfide reductase | Glutathione reduction | Gold-coordination | Homodimer | Protein gold complex
