2ajl
From Proteopedia
(New page: 200px<br /> <applet load="2ajl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ajl, resolution 2.5Å" /> '''X-ray Structure of N...) |
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| - | [[Image:2ajl.gif|left|200px]]<br /> | + | [[Image:2ajl.gif|left|200px]]<br /><applet load="2ajl" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2ajl" size=" | + | |
caption="2ajl, resolution 2.5Å" /> | caption="2ajl, resolution 2.5Å" /> | ||
'''X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor'''<br /> | '''X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The discovery, SAR, and X-ray crystal structure of novel | + | The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported. |
==About this Structure== | ==About this Structure== | ||
| - | 2AJL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG and JNH as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | + | 2AJL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=JNH:'>JNH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Abad, M | + | [[Category: Abad, M C.]] |
| - | [[Category: Baumann, C | + | [[Category: Baumann, C A.]] |
| - | [[Category: Bayoumy, S | + | [[Category: Bayoumy, S S.]] |
| - | [[Category: Crysler, C | + | [[Category: Crysler, C S.]] |
| - | [[Category: DesJarlais, R | + | [[Category: DesJarlais, R L.]] |
[[Category: Kervinen, J.]] | [[Category: Kervinen, J.]] | ||
| - | [[Category: Neeper, M | + | [[Category: Neeper, M P.]] |
| - | [[Category: Ninan, N | + | [[Category: Ninan, N S.]] |
[[Category: Qiao, L.]] | [[Category: Qiao, L.]] | ||
| - | [[Category: Spurlino, J | + | [[Category: Spurlino, J C.]] |
[[Category: JNH]] | [[Category: JNH]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:15 2008'' |
Revision as of 14:28, 21 February 2008
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X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor
Overview
The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.
About this Structure
2AJL is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.
Reference
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors., Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ, Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. Epub 2005 Oct 19. PMID:16236500
Page seeded by OCA on Thu Feb 21 16:28:15 2008
