2alv
From Proteopedia
(New page: 200px<br /><applet load="2alv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2alv, resolution 1.90Å" /> '''X-ray structural ana...) |
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==Overview== | ==Overview== | ||
| - | Design, synthesis, and biological evaluation of peptidomimetic severe | + | Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors. |
==About this Structure== | ==About this Structure== | ||
| Line 13: | Line 13: | ||
[[Category: Human sars coronavirus]] | [[Category: Human sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Baker, S | + | [[Category: Baker, S C.]] |
[[Category: Fu, W.]] | [[Category: Fu, W.]] | ||
| - | [[Category: Ghosh, A | + | [[Category: Ghosh, A K.]] |
| - | [[Category: Harcourt, B | + | [[Category: Harcourt, B H.]] |
| - | [[Category: Johnson, M | + | [[Category: Johnson, M E.]] |
| - | [[Category: Mesecar, A | + | [[Category: Mesecar, A D.]] |
[[Category: Ratia, K.]] | [[Category: Ratia, K.]] | ||
| - | [[Category: Rota, P | + | [[Category: Rota, P A.]] |
| - | [[Category: Santarsiero, B | + | [[Category: Santarsiero, B D.]] |
[[Category: Xi, K.]] | [[Category: Xi, K.]] | ||
[[Category: CY6]] | [[Category: CY6]] | ||
| Line 34: | Line 34: | ||
[[Category: sars]] | [[Category: sars]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:28:39 2008'' |
Revision as of 14:28, 21 February 2008
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X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus with as ligand. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632
Page seeded by OCA on Thu Feb 21 16:28:39 2008
Categories: Human sars coronavirus | Single protein | Baker, S C. | Fu, W. | Ghosh, A K. | Harcourt, B H. | Johnson, M E. | Mesecar, A D. | Ratia, K. | Rota, P A. | Santarsiero, B D. | Xi, K. | CY6 | 3c | 3cl | 3clpro | Anti-viral | Coronavirus | Inhibitor | Protease | Proteinase | Sars
