2ao7
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2ao7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ao7, resolution 2.9Å" /> '''Adam10 Disintegrin an...) |
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| - | [[Image:2ao7.gif|left|200px]]<br /><applet load="2ao7" size=" | + | [[Image:2ao7.gif|left|200px]]<br /><applet load="2ao7" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ao7, resolution 2.9Å" /> | caption="2ao7, resolution 2.9Å" /> | ||
'''Adam10 Disintegrin and cysteine- rich domain'''<br /> | '''Adam10 Disintegrin and cysteine- rich domain'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Ephrin ligands presented on one cell surface associate with their | + | Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease. |
==About this Structure== | ==About this Structure== | ||
| - | 2AO7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/ADAM10_endopeptidase ADAM10 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.81 3.4.24.81] Full crystallographic information is available from [http:// | + | 2AO7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/ADAM10_endopeptidase ADAM10 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.81 3.4.24.81] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AO7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Barton, W | + | [[Category: Barton, W A.]] |
| - | [[Category: Blobel, C | + | [[Category: Blobel, C P.]] |
| - | [[Category: Himanen, J | + | [[Category: Himanen, J P.]] |
| - | [[Category: Janes, P | + | [[Category: Janes, P W.]] |
| - | [[Category: Kolev, M | + | [[Category: Kolev, M V.]] |
[[Category: Lackmann, M.]] | [[Category: Lackmann, M.]] | ||
[[Category: Nievergall, E.]] | [[Category: Nievergall, E.]] | ||
| - | [[Category: Nikolov, D | + | [[Category: Nikolov, D B.]] |
[[Category: Saha, N.]] | [[Category: Saha, N.]] | ||
| - | [[Category: Wimmer-Kleikamp, S | + | [[Category: Wimmer-Kleikamp, S H.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: disintegrin]] | [[Category: disintegrin]] | ||
| Line 29: | Line 29: | ||
[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:29:19 2008'' |
Revision as of 14:29, 21 February 2008
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Adam10 Disintegrin and cysteine- rich domain
Overview
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
About this Structure
2AO7 is a Single protein structure of sequence from Bos taurus with as ligand. Active as ADAM10 endopeptidase, with EC number 3.4.24.81 Full crystallographic information is available from OCA.
Reference
ADAM and Eph: how Ephrin-signaling cells become detached., Mancia F, Shapiro L, Cell. 2005 Oct 21;123(2):185-7. PMID:16239135
Page seeded by OCA on Thu Feb 21 16:29:19 2008
