2ate
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2ate" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ate, resolution 1.80Å" /> '''Structure of the com...) |
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| - | [[Image:2ate.gif|left|200px]]<br /><applet load="2ate" size=" | + | [[Image:2ate.gif|left|200px]]<br /><applet load="2ate" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ate, resolution 1.80Å" /> | caption="2ate, resolution 1.80Å" /> | ||
'''Structure of the complex of PurE with NitroAIR'''<br /> | '''Structure of the complex of PurE with NitroAIR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Structural studies, sequence alignments, and biochemistry have provided | + | Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years. |
==About this Structure== | ==About this Structure== | ||
| - | 2ATE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NIA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] Full crystallographic information is available from [http:// | + | 2ATE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NIA:'>NIA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazole_carboxylase Phosphoribosylaminoimidazole carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.21 4.1.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Phosphoribosylaminoimidazole carboxylase]] | [[Category: Phosphoribosylaminoimidazole carboxylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Ealick, S | + | [[Category: Ealick, S E.]] |
| - | [[Category: Hoskins, A | + | [[Category: Hoskins, A A.]] |
| - | [[Category: Kappock, T | + | [[Category: Kappock, T J.]] |
| - | [[Category: Mathews, I | + | [[Category: Mathews, I I.]] |
[[Category: Okamoto, A.]] | [[Category: Okamoto, A.]] | ||
[[Category: Peng, P.]] | [[Category: Peng, P.]] | ||
[[Category: Stubbe, J.]] | [[Category: Stubbe, J.]] | ||
| - | [[Category: Zaugg, J | + | [[Category: Zaugg, J B.]] |
[[Category: NIA]] | [[Category: NIA]] | ||
[[Category: nitroair complex]] | [[Category: nitroair complex]] | ||
[[Category: pure]] | [[Category: pure]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:30:51 2008'' |
Revision as of 14:30, 21 February 2008
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Structure of the complex of PurE with NitroAIR
Overview
Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.
About this Structure
2ATE is a Single protein structure of sequence from Escherichia coli with as ligand. Active as Phosphoribosylaminoimidazole carboxylase, with EC number 4.1.1.21 Full crystallographic information is available from OCA.
Reference
Modular evolution of the purine biosynthetic pathway., Kappock TJ, Ealick SE, Stubbe J, Curr Opin Chem Biol. 2000 Oct;4(5):567-72. PMID:11006546
Page seeded by OCA on Thu Feb 21 16:30:51 2008
