2ax0
From Proteopedia
(New page: 200px<br /><applet load="2ax0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ax0, resolution 2.00Å" /> '''Hepatitis C Virus NS...) |
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| - | [[Image:2ax0.gif|left|200px]]<br /><applet load="2ax0" size=" | + | [[Image:2ax0.gif|left|200px]]<br /><applet load="2ax0" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ax0, resolution 2.00Å" /> | caption="2ax0, resolution 2.00Å" /> | ||
'''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''<br /> | '''Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with | + | Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b. |
==About this Structure== | ==About this Structure== | ||
| - | 2AX0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with SO4 and 5X as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http:// | + | 2AX0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=5X:'>5X</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AX0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Anzola, J.]] | [[Category: Anzola, J.]] | ||
| - | [[Category: Chen, J | + | [[Category: Chen, J M.]] |
| - | [[Category: Jaen, J | + | [[Category: Jaen, J C.]] |
[[Category: Lee, G.]] | [[Category: Lee, G.]] | ||
[[Category: Li, Y.]] | [[Category: Li, Y.]] | ||
[[Category: Liu, J.]] | [[Category: Liu, J.]] | ||
[[Category: Mayorga, V.]] | [[Category: Mayorga, V.]] | ||
| - | [[Category: Peterson, M | + | [[Category: Peterson, M G.]] |
| - | [[Category: Piper, D | + | [[Category: Piper, D E.]] |
| - | [[Category: Powers, J | + | [[Category: Powers, J P.]] |
| - | [[Category: Tonn, G | + | [[Category: Tonn, G R.]] |
| - | [[Category: Walker, N | + | [[Category: Walker, N P.]] |
[[Category: Wang, Z.]] | [[Category: Wang, Z.]] | ||
[[Category: Ye, Q.]] | [[Category: Ye, Q.]] | ||
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[[Category: thumb]] | [[Category: thumb]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:31:50 2008'' |
Revision as of 14:31, 21 February 2008
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Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)
Overview
Novel non-nucleoside inhibitors of the HCV RNA polymerase (NS5b) with sub-micromolar biochemical potency have been identified which are selective for the inhibition of HCV NS5b over other polymerases. The structures of the complexes formed between several of these inhibitors and HCV NS5b were determined by X-ray crystallography, and the inhibitors were found to bind in an allosteric binding site separate from the active site. Structure-activity relationships and structural studies have identified the mechanism of action for compounds in this series, several of which possess drug-like properties, as unique, reversible, covalent inhibitors of HCV NS5b.
About this Structure
2AX0 is a Single protein structure of sequence from Hepatitis c virus with and as ligands. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
Reference
SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase., Powers JP, Piper DE, Li Y, Mayorga V, Anzola J, Chen JM, Jaen JC, Lee G, Liu J, Peterson MG, Tonn GR, Ye Q, Walker NP, Wang Z, J Med Chem. 2006 Feb 9;49(3):1034-46. PMID:16451069
Page seeded by OCA on Thu Feb 21 16:31:50 2008
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Single protein | Anzola, J. | Chen, J M. | Jaen, J C. | Lee, G. | Li, Y. | Liu, J. | Mayorga, V. | Peterson, M G. | Piper, D E. | Powers, J P. | Tonn, G R. | Walker, N P. | Wang, Z. | Ye, Q. | 5X | SO4 | Fingers | Hcv | Ns5b | Palm | Polymerase | Thumb
