3c5t

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Revision as of 14:43, 6 March 2013

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Template:STRUCTURE 3c5t

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Template:ABSTRACT PUBMED 18287102

About this Structure

3c5t is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Runge S, Thogersen H, Madsen K, Lau J, Rudolph R. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem. 2008 Apr 25;283(17):11340-7. Epub 2008 Feb 20. PMID:18287102 doi:10.1074/jbc.M708740200
• Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschop MH. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol. 2009 Oct;5(10):749-57. Epub 2009 Jul 13. PMID:19597507 doi:10.1038/nchembio.209