2ayr
From Proteopedia
(New page: 200px<br /> <applet load="2ayr" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ayr, resolution 1.900Å" /> '''A SERM Designed fo...) |
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| - | [[Image:2ayr.gif|left|200px]]<br /> | + | [[Image:2ayr.gif|left|200px]]<br /><applet load="2ayr" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2ayr" size=" | + | |
caption="2ayr, resolution 1.900Å" /> | caption="2ayr, resolution 1.900Å" /> | ||
'''A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats'''<br /> | '''A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The design of a novel selective estrogen receptor modulator (SERM) for the | + | The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. 16 (LY2066948-HCl) binds with high affinity to estrogen receptors alpha and beta (ERalpha and ERbeta, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2AYR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with L4G as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2AYR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=L4G:'>L4G</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bryant, H | + | [[Category: Bryant, H U.]] |
| - | [[Category: Cohen, I | + | [[Category: Cohen, I R.]] |
| - | [[Category: Dally, R | + | [[Category: Dally, R D.]] |
| - | [[Category: Dodge, J | + | [[Category: Dodge, J A.]] |
| - | [[Category: Fong, K | + | [[Category: Fong, K C.]] |
| - | [[Category: Frank, S | + | [[Category: Frank, S A.]] |
| - | [[Category: Geiser, A | + | [[Category: Geiser, A G.]] |
[[Category: Hinklin, R.]] | [[Category: Hinklin, R.]] | ||
| - | [[Category: Hummel, C | + | [[Category: Hummel, C W.]] |
| - | [[Category: Jones, S | + | [[Category: Jones, S A.]] |
[[Category: Lewis, G.]] | [[Category: Lewis, G.]] | ||
| - | [[Category: McCann, D | + | [[Category: McCann, D J.]] |
| - | [[Category: Rudman, D | + | [[Category: Rudman, D G.]] |
| - | [[Category: Shepherd, T | + | [[Category: Shepherd, T A.]] |
[[Category: Tian, H.]] | [[Category: Tian, H.]] | ||
| - | [[Category: Wallace, O | + | [[Category: Wallace, O B.]] |
[[Category: Wang, Y.]] | [[Category: Wang, Y.]] | ||
[[Category: L4G]] | [[Category: L4G]] | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:32:31 2008'' |
Revision as of 14:32, 21 February 2008
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A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats
Contents |
Overview
The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. 16 (LY2066948-HCl) binds with high affinity to estrogen receptors alpha and beta (ERalpha and ERbeta, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation.
Disease
Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[133430], Breast cancer OMIM:[133430], Estrogen resistance OMIM:[133430], HDL response to hormone replacement, augmented OMIM:[133430], Migraine, susceptibility to OMIM:[133430], Myocardial infarction, susceptibility to OMIM:[133430]
About this Structure
2AYR is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats., Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA, J Med Chem. 2005 Nov 3;48(22):6772-5. PMID:16250633
Page seeded by OCA on Thu Feb 21 16:32:31 2008
Categories: Homo sapiens | Single protein | Bryant, H U. | Cohen, I R. | Dally, R D. | Dodge, J A. | Fong, K C. | Frank, S A. | Geiser, A G. | Hinklin, R. | Hummel, C W. | Jones, S A. | Lewis, G. | McCann, D J. | Rudman, D G. | Shepherd, T A. | Tian, H. | Wallace, O B. | Wang, Y. | L4G | Ligand-binding | Receptor | Serm | Transcription | Transcription regulation
