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3ho5
From Proteopedia
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[[Image:3ho5.png|left|200px]] | [[Image:3ho5.png|left|200px]] | ||
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{{STRUCTURE_3ho5| PDB=3ho5 | SCENE= }} | {{STRUCTURE_3ho5| PDB=3ho5 | SCENE= }} | ||
===Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex=== | ===Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex=== | ||
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{{ABSTRACT_PUBMED_19561609}} | {{ABSTRACT_PUBMED_19561609}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Coloboma, ocular OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Holoprosencephaly-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Microphthalmia, isolated, with coloboma 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Solitary median maxillary central incisor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3ho5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HO5 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019561609</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bosanac, I.]] | [[Category: Bosanac, I.]] | ||
[[Category: Hymowitz, S G.]] | [[Category: Hymowitz, S G.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Autocatalytic cleavage]] | [[Category: Autocatalytic cleavage]] | ||
[[Category: Calcium cation]] | [[Category: Calcium cation]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Developmental protein]] | [[Category: Developmental protein]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
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[[Category: Microphthalmia]] | [[Category: Microphthalmia]] | ||
[[Category: Palmitate]] | [[Category: Palmitate]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Receptor ectodomain]] | [[Category: Receptor ectodomain]] | ||
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[[Category: Six-bladed-propeller domain]] | [[Category: Six-bladed-propeller domain]] | ||
[[Category: Zinc cation]] | [[Category: Zinc cation]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:48:23 2010'' | ||
Revision as of 14:56, 6 March 2013
Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex
Template:ABSTRACT PUBMED 19561609
About this Structure
3ho5 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. Epub 2009 Jun 28. PMID:19561609 doi:10.1038/nsmb.1632
Categories: Homo sapiens | Bosanac, I. | Hymowitz, S G. | Autocatalytic cleavage | Calcium cation | Cell membrane | Developmental protein | Disease mutation | Disulfide bond | Egf domain | Egf-like domain | Glycoprotein | Holoprosencephaly | Hydrolase | Lipoprotein | Membrane | Microphthalmia | Palmitate | Protease | Receptor ectodomain | Secreted | Signaling protein | Six-bladed-propeller domain | Zinc cation
