2b1p
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The structure-based design and synthesis of a new series of c-Jun | + | The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site. |
==Disease== | ==Disease== | ||
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[[Category: Malmstrom, J.]] | [[Category: Malmstrom, J.]] | ||
[[Category: Ohberg, L.]] | [[Category: Ohberg, L.]] | ||
| - | [[Category: Swahn, B | + | [[Category: Swahn, B M.]] |
[[Category: Viklund, J.]] | [[Category: Viklund, J.]] | ||
[[Category: Weigelt, T.]] | [[Category: Weigelt, T.]] | ||
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[[Category: kinase inhibitor]] | [[Category: kinase inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:17 2008'' |
Revision as of 14:33, 21 February 2008
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inhibitor complex of JNK3
Contents |
Overview
The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.
Disease
Known diseases associated with this structure: Epileptic encephalopathy, Lennox-Gastaut type OMIM:[602897]
About this Structure
2B1P is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3., Swahn BM, Huerta F, Kallin E, Malmstrom J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L, Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9. PMID:16140012
Page seeded by OCA on Thu Feb 21 16:33:17 2008
