Adenylate kinase

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[[Image:3l0p.jpg|left|200px|thumb|Crystal Structure of Adenylate kinase [[3l0p]]]]
[[Image:3l0p.jpg|left|200px|thumb|Crystal Structure of Adenylate kinase [[3l0p]]]]
{{STRUCTURE_3l0p| PDB=3l0p | SIZE=400| SCENE= |right|CAPTION=Adenylate kinase complex with iron and glycerol [[3l0p]] }}
{{STRUCTURE_3l0p| PDB=3l0p | SIZE=400| SCENE= |right|CAPTION=Adenylate kinase complex with iron and glycerol [[3l0p]] }}
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Revision as of 09:45, 7 March 2013

Image:3l0p.jpg
Crystal Structure of Adenylate kinase 3l0p

Template:STRUCTURE 3l0p









Adenylate kinase (ADK, EC number 2.7.4.3) is a phosphotransferase which catalyzes the interconversion of ADP to ATP+AMP. ADK is important in cellular energy homeostasis. Dinucleotides polyphosphates like diadenosine pentaphosphate (AP5) inhibit ADK. The images at the left and at the right correspond to one representative ADK, i.e. the crystal structure of Adenylate kinase from Desulfovibrio gigas (3l0p).


3l0p Crystal structure of cobalt bound adenylate kinase from Desulfovibrio gigas

Drag the structure with the mouse to rotate


Contents

3D Structures of Adenylate kinase

Updated on 07-March-2013

ADK unliganded

4ake - EcADK - Escherichia coli
3gmt - ADK - Burkholderia pseudodomallei
3cm0 - ADK - Thermus thermophilus
2rh5 - AaADK - Aquifex aeolicus
1p4s - MtADK - Mycobacterium tuberculosis
2ar7 - hADK 4 - human
3ndp - hADK 4 (mutant)
3iij, 3iik – hADK 6
1ki9 - ADK - Methanococcus thermolithotrophicus
1ak2, 2ak2 - bADK - bovine
3adk - ADK - pig
3be4 - CpADK – Cryptosporidium parvum
3tlx – ADK 2 – Plasmodium falciparum

ADK mononucleotide complex

1ank - EcADK+AMP+AMPPNP
2cdn - MtADK+ADP
2bwj - hADK 5+AMP
3iil – hADK 6 + MgADP-Pi
3iim – hADK 6 + DADP
1kht - ADK+AMP - Methanococcus voltae
1nks - ADK+AMP+ADP - Sulfolobus acidocaldarius
2ak3 - bADK+AMP
1dvr - yADK (mutant)+ATP analog - yeast

ADK complex with dinucletide polyphosphates

3hpq, 3hpr, 1e4v, 1e4y - EcADK (mutant)+AP5
1ake - EcADK+AP5
3h86 - ADK+AP5 - Methanococcus maripaludis
3fb4 - ADK+Zn+AP5 - Marinibacillus marinus
3dkv, 3dl0, 1p3j - BsADK+Zn+AP5 - Bacillus subtilis
2qaj, 2oo7, 2p3s, 2ori, 2osb, 2eu8 - BsADK (mutant)+Zn+AP5
2rgx - AaADK+Zn+AP5
3be4 - CpADK+AP5
2c9y - hADK 2+bis-adenosine tetraphosphate
2bbw - hADK 4+GP5
1s3g - ADK+Zn+AP5 - Bacillus globisporus
1zak - ADK+AP5 - maize
1zip, 1zin - ADK+Zn+Mn+AP5 - Bacillus stearothermophilus
1aky, 2aky - yADK+AP5
3aky - yADK (mutant)+AP5

ADK complexes with ions

3l0p - DgADK+Fe - Desulfovibrio gigas
3l0s - DgADK+Co
2xb4 - DgADK+Zn

References

  1. ↑ Mukhopadhyay A, Kladova AV, Bursakov SA, Gavel OY, Calvete JJ, Shnyrov VL, Moura I, Moura JJ, Romao MJ, Trincao J. Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria. J Biol Inorg Chem. 2010 Sep 7. PMID:20821240 doi:10.1007/s00775-010-0700-8

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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