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Asparaginase
From Proteopedia
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==3D structures of asparaginase== | ==3D structures of asparaginase== | ||
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===ASP I=== | ===ASP I=== | ||
Revision as of 10:13, 7 March 2013
Asparaginase (ASP) catalyzes the conversion of asparagine to aspartic acid (AA). ASP I is used in the food processing industry to reduce the formation of the carcinogen acrylamide in the production of starchy food products. A different kind of ASP – ASP II – is used as drug (Elspar) in the treatment of cancer such as acute lymphoblastic leukemia (ALL). The ALL cells require high concentrations of asparagine which becomes scarce when high doses of ASP are present.
3D structures of asparaginase
Updated on 07-March-2013
ASP I
1hfj, 1hfk, 1o7j - ErcASP – Erwinia chrysanthemi
1wnf - ASP – Pyrococcus horikoshii
1zcf - PaASP – Pectobacterium atrosepticum
1gez - ASP – yellow lupine
2ocd - ASP – Vibrio cholera
2p2d - EcASP – Eschericia coli
3ntx - ASP – Yersinia pestis
3nxk - ASP – Campylobacter jejuni
4gdu - hASP – human
ASP I complex
1hfw - ErcASP + glutamate
2p2n - PaASP + glutamate
1hg0 - ErcASP + succinate
1hg1 - ErcASP + D-AA
2gvn - PaSP + AA
2jk0 - ASP + AA – Pectobacterium carotovorum
2wlt, 2wt4 - ASP + AA – Helicobacter pylori
2him, 2zal - EcASP + AA
2p2n - EcASP + asparagine + AA
1jsl, 1jsr - ErcASP + norleucine
4gdt - hASP + malonate
4gdv, 4gdw - hASP + AA
ASP II
1wsa – ASP precursor – Wolinella succinogenes
1ihd, 1jaz, 1jja - EcASP (mutant)
ASP II complex
3eca, 4eca, 1nns – EcASP + AA
1ho3 - EcASP (mutant) + AA
2zak, 3c17 - EcASP precursor (mutant)
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