2b2r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2b2r" size="350" color="white" frame="true" align="right" spinBox="true" caption="2b2r, resolution 1.90&Aring;" /> '''Crystal structure of...)
Line 4: Line 4:
==Overview==
==Overview==
-
The catalase reaction of catalase-peroxidases involves catalase-specific, features built into a peroxidase core. An arginine, 20 A from the, active-site heme, acts as a molecular switch moving between two, conformations, one that activates heme oxidation and one that activates, oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway, in a peroxidase. The influence of the arginine is imparted to the heme, through its association with or dissociation from a tyrosinate that, modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi, electron interaction of the heme with the adduct Trp.
+
The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.
==About this Structure==
==About this Structure==
Line 18: Line 18:
[[Category: Fita, I.]]
[[Category: Fita, I.]]
[[Category: Ivancich, A.]]
[[Category: Ivancich, A.]]
-
[[Category: Loewen, P.C.]]
+
[[Category: Loewen, P C.]]
[[Category: Singh, R.]]
[[Category: Singh, R.]]
[[Category: Switala, J.]]
[[Category: Switala, J.]]
Line 30: Line 30:
[[Category: oxoferryl species]]
[[Category: oxoferryl species]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:15:10 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:31 2008''

Revision as of 14:33, 21 February 2008

Image:2b2r.gif

2b2r, resolution 1.90Å

Drag the structure with the mouse to rotate

Crystal structure of an oxoferryl species of catalase-peroxidase KATG at pH5.6

Overview

The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.

About this Structure

2B2R is a Single protein structure of sequence from Burkholderia pseudomallei with , and as ligands. Active as Catalase, with EC number 1.11.1.6 Full crystallographic information is available from OCA.

Reference

A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084

Page seeded by OCA on Thu Feb 21 16:33:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b2r"
Personal tools