Cocaine esterase
From Proteopedia
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==3D structures of cocaine esterase== | ==3D structures of cocaine esterase== | ||
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[[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | [[3i2j]], [[3puh]] - RhCocE – ''Rhodococcus''<br /> | ||
Revision as of 11:13, 7 March 2013
Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser]], [[Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse.
3D structures of cocaine esterase
Updated on 07-March-2013
3i2j, 3puh - RhCocE – Rhodococcus
1l7r, 3pui - RhCocE (mutant)
Cocaine esterase binary complex
1ju3 – RhCocE + transition state inhibitor
1ju4 – RhCocE + benzoic acid
1l7q - RhCocE (mutant) + benzoic acid
3ida, 3i2f, 3i2g, 3i2h, 3i2i - RhCocE (mutant) + DTT derivative
3i2k - RhCocE + DTT derivative
