Plasmepsin
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3fns.jpg|left|thumb|300px|Crystal Strcture of the Plasmepsin, [[3fns]]]] | ||
{{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin dimer witn Zn+2 ions, [[3fns]] }} | {{STRUCTURE_3fns| right| PDB=3fns | SCENE= |CAPTION=Plasmepsin dimer witn Zn+2 ions, [[3fns]] }} | ||
| - | |||
[[Plasmepsin]] (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, ''i.e.'' the Plasmepsin from ''Plasmodium falciparum'' ([[3fns]]). | [[Plasmepsin]] (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, ''i.e.'' the Plasmepsin from ''Plasmodium falciparum'' ([[3fns]]). | ||
| Line 14: | Line 12: | ||
<br /> | <br /> | ||
| - | + | Updated: {{REVISIONDAY2}}-{{REVISIONMONTH}}-{{REVISIONYEAR}} (DD-MM-YYYY) | |
===HAP=== | ===HAP=== | ||
Revision as of 13:46, 10 March 2013
Template:STRUCTURE 3fns Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, i.e. the Plasmepsin from Plasmodium falciparum (3fns).
3D Structures of Plasmepsin
Updated: 10-3-2013 (DD-MM-YYYY)
HAP
3fns – PfHAP - Plasmodium falciparum
3fnt – PfHAP + inhibitor pepstatin
3fnu – PfHAP + KNI-10006
Plm I
3qrv – PfPlm I residues 117-457
3qs1 - PfPlm I residues 117-457 + inhibitor
Plm II
1lf4 – PfPlm II
3f9q – PfPlm II (mutant)
2r9b – PfPlm II + peptide inhibitor
1w6h, 2bju, 1lf2, 1lf3, 1lee, 2igx, 2igy – PfPlm II + inhibitor
1w6i, 1xdh, 1xe5, 1xe6, 1me6, 1sme – PfPlm II + pepstatin derivative
1m43 - PfPlm II (mutant) + pepstatin derivative
ProPlm II
1pfz - PfProPlm II
1miq – PvProPlm II – Plasmodium vivax
1qs8 - PvPlm + pepstatin derivative
Plm IV
2anl – Plm IV + statine derivative – Plasmodium malariae
1ls5 - PfPlm IV + pepstatin derivative
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
