2b4c
From Proteopedia
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| - | [[Image:2b4c.gif|left|200px]]<br /> | + | [[Image:2b4c.gif|left|200px]]<br /><applet load="2b4c" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2b4c" size=" | + | |
caption="2b4c, resolution 3.30Å" /> | caption="2b4c, resolution 3.30Å" /> | ||
'''Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody'''<br /> | '''Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is | + | The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization. |
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| + | ==Disease== | ||
| + | Known diseases associated with this structure: CD4 lymphocyte deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]], Lupus erythematosus, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=186940 186940]] | ||
==About this Structure== | ==About this Structure== | ||
| - | 2B4C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with NAG, NDG, XYL and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2B4C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=XYL:'>XYL</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4C OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Dimitrov, D | + | [[Category: Dimitrov, D S.]] |
[[Category: Huang, C.]] | [[Category: Huang, C.]] | ||
[[Category: Korber, B.]] | [[Category: Korber, B.]] | ||
| - | [[Category: Kwong, P | + | [[Category: Kwong, P D.]] |
[[Category: Majeed, S.]] | [[Category: Majeed, S.]] | ||
[[Category: Montabana, E.]] | [[Category: Montabana, E.]] | ||
[[Category: Sodroski, J.]] | [[Category: Sodroski, J.]] | ||
| - | [[Category: Stanfield, R | + | [[Category: Stanfield, R L.]] |
[[Category: Tang, M.]] | [[Category: Tang, M.]] | ||
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: Wyatt, R.]] | [[Category: Wyatt, R.]] | ||
| - | [[Category: Zhang, M | + | [[Category: Zhang, M Y.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: NDG]] | [[Category: NDG]] | ||
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[[Category: x5]] | [[Category: x5]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:34:00 2008'' |
Revision as of 14:34, 21 February 2008
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Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody
Contents |
Overview
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
Disease
Known diseases associated with this structure: CD4 lymphocyte deficiency OMIM:[186940], Lupus erythematosus, susceptibility to OMIM:[186940]
About this Structure
2B4C is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1 with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of a V3-containing HIV-1 gp120 core., Huang CC, Tang M, Zhang MY, Majeed S, Montabana E, Stanfield RL, Dimitrov DS, Korber B, Sodroski J, Wilson IA, Wyatt R, Kwong PD, Science. 2005 Nov 11;310(5750):1025-8. PMID:16284180
Page seeded by OCA on Thu Feb 21 16:34:00 2008
Categories: Homo sapiens | Human immunodeficiency virus 1 | Protein complex | Dimitrov, D S. | Huang, C. | Korber, B. | Kwong, P D. | Majeed, S. | Montabana, E. | Sodroski, J. | Stanfield, R L. | Tang, M. | Wilson, I A. | Wyatt, R. | Zhang, M Y. | NAG | NDG | SO4 | XYL | Cd4 induced antibody | Gp120 | Hiv-1 | Jrfl | V3 | X5
