2g19

From Proteopedia

Revision as of 09:10, 11 March 2013

spinqualitylabelsall models PDB ID 2g19 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2g19, resolution 1.70Å ()
Ligands:	,
Structural annotation: Resources: InterPro : Ipr002893, Ipr005123, Ipr006620 Pfam : PF03171 UniProt : Q9GZT9
Functional annotation: Cellular component: cytosol Biological process: protein metabolic process Molecular function: protein binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen L-ascorbic acid binding metal ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors iron ion binding zinc ion binding oxidoreductase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

Template:ABSTRACT PUBMED 16782814

About this Structure

2g19 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hypoxia-inducible factor prolyl hydroxylase
• Molecular Playground/Prolyl Hydroxylase Domain (PHD) Enzyme
• Prolyl hydroxylase domain

Reference

• McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Lienard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. Epub 2006 Jun 16. PMID:16782814