3fpn
From Proteopedia
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===Crystal structure of UvrA-UvrB interaction domains=== | ===Crystal structure of UvrA-UvrB interaction domains=== | ||
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==See Also== | ==See Also== | ||
| - | *[[User:Wayne Decatur|User:Wayne Decatur]] | ||
| - | *[[User:Wayne Decatur/3ewsSLASH3g0h Morph methods|User:Wayne Decatur/3ewsSLASH3g0h Morph methods]] | ||
| - | *[[User:Wayne Decatur/3fpn Morph methods|User:Wayne Decatur/3fpn Morph methods]] | ||
*[[UvrA-UvrB interaction domains|UvrA-UvrB interaction domains]] | *[[UvrA-UvrB interaction domains|UvrA-UvrB interaction domains]] | ||
Revision as of 09:40, 11 March 2013
Contents |
Crystal structure of UvrA-UvrB interaction domains
Nucleotide excision repair is distinguished from other DNA repair pathways by its ability to process a wide range of structurally unrelated DNA lesions. In bacteria, damage recognition is achieved by the UvrA.UvrB ensemble. Here, we report the structure of the complex between the interaction domains of UvrA and UvrB. These domains are necessary and sufficient for full-length UvrA and UvrB to associate and thereby form the DNA damage-sensing complex of bacterial nucleotide excision repair. The crystal structure and accompanying biochemical analyses suggest a model for the complete damage-sensing complex.
A structural model for the damage-sensing complex in bacterial nucleotide excision repair., Pakotiprapha D, Liu Y, Verdine GL, Jeruzalmi D, J Biol Chem. 2009 May 8;284(19):12837-44. Epub 2009 Mar 13. PMID:19287003
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3fpn is a 2 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
See Also
Reference
- Pakotiprapha D, Liu Y, Verdine GL, Jeruzalmi D. A structural model for the damage-sensing complex in bacterial nucleotide excision repair. J Biol Chem. 2009 May 8;284(19):12837-44. Epub 2009 Mar 13. PMID:19287003 doi:10.1074/jbc.M900571200
