2bbb
From Proteopedia
(New page: 200px<br /> <applet load="2bbb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bbb, resolution 1.70Å" /> '''Structure of HIV1 p...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2bbb.gif|left|200px]]<br /> | + | [[Image:2bbb.gif|left|200px]]<br /><applet load="2bbb" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2bbb" size=" | + | |
caption="2bbb, resolution 1.70Å" /> | caption="2bbb, resolution 1.70Å" /> | ||
'''Structure of HIV1 protease and hh1_173_3a complex.'''<br /> | '''Structure of HIV1 protease and hh1_173_3a complex.'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A series of monopyrrolinone-based HIV-1 protease inhibitors possessing | + | A series of monopyrrolinone-based HIV-1 protease inhibitors possessing rationally designed P2' side chains have been synthesized and evaluated for activity against wild-type HIV-1 protease. The most potent inhibitor displays subnanomolar potency in vitro for the wild-type HIV-1 protease. Additionally, the monopyrrolinone inhibitors retain potency in cellular assays against clinically significant mutant forms of the virus. X-ray structures of these inhibitors bound in the wild-type enzyme reveal important insights into the observed biological activity. |
==About this Structure== | ==About this Structure== | ||
| - | 2BBB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with HH1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http:// | + | 2BBB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=HH1:'>HH1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBB OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 14: | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Charnley, A | + | [[Category: Charnley, A K.]] |
| - | [[Category: III, A | + | [[Category: III, A B.Smith.]] |
| - | [[Category: Kuo, L | + | [[Category: Kuo, L C.]] |
[[Category: Munshi, S.]] | [[Category: Munshi, S.]] | ||
[[Category: HH1]] | [[Category: HH1]] | ||
| Line 23: | Line 22: | ||
[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:35:55 2008'' |
Revision as of 14:35, 21 February 2008
|
Structure of HIV1 protease and hh1_173_3a complex.
Overview
A series of monopyrrolinone-based HIV-1 protease inhibitors possessing rationally designed P2' side chains have been synthesized and evaluated for activity against wild-type HIV-1 protease. The most potent inhibitor displays subnanomolar potency in vitro for the wild-type HIV-1 protease. Additionally, the monopyrrolinone inhibitors retain potency in cellular assays against clinically significant mutant forms of the virus. X-ray structures of these inhibitors bound in the wild-type enzyme reveal important insights into the observed biological activity.
About this Structure
2BBB is a Single protein structure of sequence from Human immunodeficiency virus 1 with as ligand. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
Reference
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains., Smith AB 3rd, Charnley AK, Harada H, Beiger JJ, Cantin LD, Kenesky CS, Hirschmann R, Munshi S, Olsen DB, Stahlhut MW, Schleif WA, Kuo LC, Bioorg Med Chem Lett. 2006 Feb 15;16(4):859-63. Epub 2005 Nov 18. PMID:16298527
Page seeded by OCA on Thu Feb 21 16:35:55 2008
