2clt

(Difference between revisions)

Revision as of 10:26, 11 March 2013

2clt, resolution 2.67Å ()

Ligands:

Activity:

Interstitial collagenase, with EC number 3.4.24.7

Related:

Structural annotation:
Resources:	CATH : 2Clta02, 2Clta01, 2Cltb01, 2Cltb02 InterPro : Ipr002477, Ipr001818, Ipr006026, Ipr000585, Ipr006025 Pfam : PF00045, PF00413 UniProt : P03956

Functional annotation:
Cellular component:	proteinaceous extracellular matrix extracellular space
Biological process:	metabolic process collagen catabolic process proteolysis
Molecular function:	zinc ion binding hydrolase activity peptidase activity metal ion binding catalytic activity calcium ion binding collagenase activity metallopeptidase activity interstitial collagenase activity metalloendopeptidase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2clt is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Iyer S, Visse R, Nagase H, Acharya KR. Crystal structure of an active form of human MMP-1. J Mol Biol. 2006 Sep 8;362(1):78-88. Epub 2006 Aug 4. PMID:16890240 doi:10.1016/j.jmb.2006.06.079

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-[[Image:2clt.png|left|200px]]
 {{STRUCTURE_2clt|  PDB=2clt  |  SCENE=  }}
 ===CRYSTAL STRUCTURE OF THE ACTIVE FORM (FULL-LENGTH) OF HUMAN FIBROBLAST COLLAGENASE.===
 {{ABSTRACT_PUBMED_16890240}}