2bkf

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==Overview==
==Overview==
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The scaffold protein NBR1 is involved in signal transmission downstream of, the serine/protein kinase from the giant muscle protein titin. Its, N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating, protein-protein interactions with both titin kinase and with another, scaffold protein, p62. We have determined the crystal structure of the PB1, domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with, two negatively charged residue clusters. We provide a structural, perspective on the involvement of NBR1 in the titin kinase signalling, pathway.
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The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein-protein interactions with both titin kinase and with another scaffold protein, p62. We have determined the crystal structure of the PB1 domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with two negatively charged residue clusters. We provide a structural perspective on the involvement of NBR1 in the titin kinase signalling pathway.
==About this Structure==
==About this Structure==
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[[Category: zinc-finger]]
[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:25:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:45 2008''

Revision as of 14:38, 21 February 2008

Image:2bkf.gif

2bkf, resolution 1.56Å

Drag the structure with the mouse to rotate

STRUCTURE OF THE PB1 DOMAIN OF NBR1

Overview

The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein-protein interactions with both titin kinase and with another scaffold protein, p62. We have determined the crystal structure of the PB1 domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with two negatively charged residue clusters. We provide a structural perspective on the involvement of NBR1 in the titin kinase signalling pathway.

About this Structure

2BKF is a Single protein structure of sequence from Homo sapiens with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Crystal structure of the PB1 domain of NBR1., Muller S, Kursula I, Zou P, Wilmanns M, FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PMID:16376336

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