1o91

From Proteopedia

Revision as of 13:42, 30 October 2007

CRYSTAL STRUCTURE OF A COLLAGEN VIII NC1 DOMAIN TRIMER

Overview

Collagen VIII is a major component of Descemet's membrane and is also, found in vascular subendothelial matrices. The C-terminal non-collagenous, domain (NC1) domain of collagen VIII, which is a member of the C1q-like, protein family, forms a stable trimer and is thought to direct the, assembly of the collagen triple helix, as well as polygonal supramolecular, structures. We have solved the crystal structure of the mouse, alpha1(VIII)(3) NC1 domain trimer at 1.9 A resolution. Each subunit of the, intimate NC1 trimer consists of a ten-stranded beta-sandwich. The surface, of the collagen VIII NC1 trimer presents three strips of partially exposed, aromatic residues shown to interact with the non-ionic detergent CHAPS, which are likely to be involved in supramolecular assemblies. Equivalent, ... [(full description)]

About this Structure

1O91 is a [Single protein] structure of sequence from [Mus musculus] with SO4 and CPS as [ligands]. Structure known Active Site: SO4. Full crystallographic information is available from [OCA].

Reference

Crystal structure of the collagen alpha1(VIII) NC1 trimer., Kvansakul M, Bogin O, Hohenester E, Yayon A, Matrix Biol. 2003 Apr;22(2):145-52. PMID:12782141

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