1mu8

From Proteopedia

proteopedia linkproteopedia link

Revision as of 19:09, 20 October 2012 (edit) OCA (Talk | contribs) ← Previous diff		Revision as of 09:30, 13 March 2013 (edit) (undo) OCA (Talk | contribs) Next diff →
Line 1:		Line 1:
-	[[Image:1mu8.png|left|200px]]
-
	{{STRUCTURE_1mu8| PDB=1mu8 | SCENE= }}		{{STRUCTURE_1mu8| PDB=1mu8 | SCENE= }}
-
	===thrombin-hirugen_l-378,650===		===thrombin-hirugen_l-378,650===
-
	{{ABSTRACT_PUBMED_12570369}}		{{ABSTRACT_PUBMED_12570369}}

---

Revision as of 09:30, 13 March 2013

Template:STRUCTURE 1mu8

Contents 1 thrombin-hirugen_l-378,650 2 About this Structure 3 See Also 4 Reference

thrombin-hirugen_l-378,650

Template:ABSTRACT PUBMED 12570369

About this Structure

1mu8 is a 3 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Hirudin
• Thrombin

Reference

• Burgey CS, Robinson KA, Lyle TA, Sanderson PE, Lewis SD, Lucas BJ, Krueger JA, Singh R, Miller-Stein C, White RB, Wong B, Lyle EA, Williams PD, Coburn CA, Dorsey BD, Barrow JC, Stranieri MT, Holahan MA, Sitko GR, Cook JJ, McMasters DR, McDonough CM, Sanders WM, Wallace AA, Clayton FC, Bohn D, Leonard YM, Detwiler TJ Jr, Lynch JJ Jr, Yan Y, Chen Z, Kuo L, Gardell SJ, Shafer JA, Vacca JP. Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines. J Med Chem. 2003 Feb 13;46(4):461-73. PMID:12570369 doi:http://dx.doi.org/10.1021/jm020311f