2boo
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal | + | Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal of promutagenic uracil from single- and double-stranded DNA, thereby initiating the base-excision repair (BER) pathway. Uracil in DNA can occur by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by deamination of cytosine, resulting in U-A or U-G mispairs. The radiation-resistant bacterium Deinococcus radiodurans has an elevated number of uracil-DNA glycosylases compared with most other organisms. The crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been shown to be the major contributor to the removal of mis-incorporated uracil bases in crude cell extracts of D. radiodurans, is reported. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Mcsweeney, S.]] | [[Category: Mcsweeney, S.]] | ||
[[Category: Moe, E.]] | [[Category: Moe, E.]] | ||
| - | [[Category: Smalas, A | + | [[Category: Smalas, A O.]] |
[[Category: NO3]] | [[Category: NO3]] | ||
[[Category: base excision repair]] | [[Category: base excision repair]] | ||
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[[Category: uracil-dna glycosylase]] | [[Category: uracil-dna glycosylase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:39:59 2008'' |
Revision as of 14:40, 21 February 2008
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THE CRYSTAL STRUCTURE OF URACIL-DNA N-GLYCOSYLASE (UNG) FROM DEINOCOCCUS RADIODURANS.
Overview
Uracil-DNA glycosylases are DNA-repair enzymes that catalyse the removal of promutagenic uracil from single- and double-stranded DNA, thereby initiating the base-excision repair (BER) pathway. Uracil in DNA can occur by mis-incorporation of dUMP in place of dTMP during DNA synthesis or by deamination of cytosine, resulting in U-A or U-G mispairs. The radiation-resistant bacterium Deinococcus radiodurans has an elevated number of uracil-DNA glycosylases compared with most other organisms. The crystal structure of dr0689 (uracil-DNA N-glycosylase), which has been shown to be the major contributor to the removal of mis-incorporated uracil bases in crude cell extracts of D. radiodurans, is reported.
About this Structure
2BOO is a Single protein structure of sequence from Deinococcus radiodurans with as ligand. Active as Uridine nucleosidase, with EC number 3.2.2.3 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans., Leiros I, Moe E, Smalas AO, McSweeney S, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1049-56. Epub 2005, Jul 20. PMID:16041069
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