2bop
From Proteopedia
(New page: 200px<br /><applet load="2bop" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bop, resolution 1.700Å" /> '''CRYSTAL STRUCTURE A...) |
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| - | [[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size=" | + | [[Image:2bop.gif|left|200px]]<br /><applet load="2bop" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bop, resolution 1.700Å" /> | caption="2bop, resolution 1.700Å" /> | ||
'''CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET'''<br /> | '''CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The dominant transcriptional regulator of the papillomaviruses, E2, binds | + | The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair. |
==About this Structure== | ==About this Structure== | ||
| - | 2BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with YB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2BOP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1] with <scene name='pdbligand=YB:'>YB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bovine papillomavirus type 1]] | [[Category: Bovine papillomavirus type 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Grossman, S | + | [[Category: Grossman, S R.]] |
| - | [[Category: Hegde, R | + | [[Category: Hegde, R S.]] |
| - | [[Category: Laimins, L | + | [[Category: Laimins, L A.]] |
| - | [[Category: Sigler, P | + | [[Category: Sigler, P B.]] |
[[Category: YB]] | [[Category: YB]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
[[Category: protein-dna complex]] | [[Category: protein-dna complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:40:00 2008'' |
Revision as of 14:40, 21 February 2008
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CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET
Overview
The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.
About this Structure
2BOP is a Single protein structure of sequence from Bovine papillomavirus type 1 with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target., Hegde RS, Grossman SR, Laimins LA, Sigler PB, Nature. 1992 Oct 8;359(6395):505-12. PMID:1328886
Page seeded by OCA on Thu Feb 21 16:40:00 2008
