3i5n
From Proteopedia
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{{STRUCTURE_3i5n| PDB=3i5n | SCENE= }} | {{STRUCTURE_3i5n| PDB=3i5n | SCENE= }} | ||
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===Crystal structure of c-Met with triazolopyridazine inhibitor 13=== | ===Crystal structure of c-Met with triazolopyridazine inhibitor 13=== | ||
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{{ABSTRACT_PUBMED_19819693}} | {{ABSTRACT_PUBMED_19819693}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3i5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5N OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019819693</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Long, A M.]] | [[Category: Long, A M.]] | ||
[[Category: Whittington, D A.]] | [[Category: Whittington, D A.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
| - | [[Category: Chromosomal rearrangement]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Disulfide bond]] | [[Category: Disulfide bond]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:54:31 2010'' | ||
Revision as of 10:40, 13 March 2013
Crystal structure of c-Met with triazolopyridazine inhibitor 13
Template:ABSTRACT PUBMED 19819693
About this Structure
3i5n is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. Epub 2009 Sep 27. PMID:19819693 doi:10.1016/j.bmcl.2009.09.096
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Bellon, S F. | Boezio, A A. | Long, A M. | Whittington, D A. | Atp-binding | Disease mutation | Disulfide bond | Glycoprotein | Hgf/sf | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Proto-oncogene | Receptor | Receptor tyrosine kinase | Rtk | Scatter factor receptor | Transferase | Transmembrane | Tyrosine-protein kinase
