2bv7
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Glycolipids participate in many important cellular processes and they are | + | Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Airenne, T | + | [[Category: Airenne, T T.]] |
[[Category: Kidron, H.]] | [[Category: Kidron, H.]] | ||
[[Category: Mattjus, P.]] | [[Category: Mattjus, P.]] | ||
[[Category: Nylund, M.]] | [[Category: Nylund, M.]] | ||
[[Category: Nymalm, Y.]] | [[Category: Nymalm, Y.]] | ||
| - | [[Category: Salminen, T | + | [[Category: Salminen, T A.]] |
[[Category: West, G.]] | [[Category: West, G.]] | ||
[[Category: GM3]] | [[Category: GM3]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:41:56 2008'' |
Revision as of 14:41, 21 February 2008
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CRYSTAL STRUCTURE OF GLTP WITH BOUND GM3
Overview
Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties.
About this Structure
2BV7 is a Single protein structure of sequence from Bos taurus with and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural evidence for adaptive ligand binding of glycolipid transfer protein., Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA, J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699
Page seeded by OCA on Thu Feb 21 16:41:56 2008
Categories: Bos taurus | Single protein | Airenne, T T. | Kidron, H. | Mattjus, P. | Nylund, M. | Nymalm, Y. | Salminen, T A. | West, G. | GM3 | SO4 | Acetylation | Glycolipid | Glycolipid transfer protein | Ligand binding | Lipid transport | Repeat | Transport
