3i64

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Revision as of 11:07, 13 March 2013

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Template:STRUCTURE 3i64

Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH) and 1,4-dihydroxy-2-naphthoic acid (DHN)

Template:ABSTRACT PUBMED 19702337

About this Structure

3i64 is a 2 chain structure with sequence from Streptomyces carzinostaticus subsp. neocarzinostaticus. Full crystallographic information is available from OCA.

Reference

• Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 2009 Aug 25. PMID:19702337 doi:10.1021/bi901257q