Cobra venom factor
From Proteopedia
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| - | Cobra Venom factor is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites. | + | '''Cobra Venom factor''' is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites. |
Revision as of 11:17, 13 March 2013
Cobra Venom factor is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.
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Michal Harel, Gary A. Toumas, Alexander Berchansky, Joel L. Sussman
