2bx5
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Antibodies are the archetypal molecules of the Ig-fold superfamily. Their | + | Antibodies are the archetypal molecules of the Ig-fold superfamily. Their highly conserved beta-sheet architecture has evolved to avoid aggregation by protecting edge strands. However, the crystal structure of a human V kappa domain described here, reveals an exposed beta-edge strand which mediates assembly of a helical pentadecameric oligomer. This edge strand is highly conserved in V kappa domains but is both shortened and capped by the use of two sequential trans-proline residues in V lambda domains. We suggest that the exposure of this beta-edge in V kappa domains may explain why light-chain deposition disease is mediated predominantly by kappa antibodies. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: James, L | + | [[Category: James, L C.]] |
[[Category: aggregation]] | [[Category: aggregation]] | ||
[[Category: amyloid]] | [[Category: amyloid]] | ||
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[[Category: light-chain]] | [[Category: light-chain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:42:32 2008'' |
Revision as of 14:42, 21 February 2008
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IS FR1 THE ANTIBODY'S ACHILLIES HEEL
Overview
Antibodies are the archetypal molecules of the Ig-fold superfamily. Their highly conserved beta-sheet architecture has evolved to avoid aggregation by protecting edge strands. However, the crystal structure of a human V kappa domain described here, reveals an exposed beta-edge strand which mediates assembly of a helical pentadecameric oligomer. This edge strand is highly conserved in V kappa domains but is both shortened and capped by the use of two sequential trans-proline residues in V lambda domains. We suggest that the exposure of this beta-edge in V kappa domains may explain why light-chain deposition disease is mediated predominantly by kappa antibodies.
About this Structure
2BX5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Beta-edge interactions in a pentadecameric human antibody V kappa domain., James LC, Jones PC, McCoy A, Tennent GA, Pepys MB, Famm K, Winter G, J Mol Biol. 2007 Mar 30;367(3):603-8. Epub 2006 Nov 3. PMID:17292396
Page seeded by OCA on Thu Feb 21 16:42:32 2008
Categories: Escherichia coli | Single protein | James, L C. | Aggregation | Amyloid | Antibody | Fr1 | Lcdd | Light-chain
