2bzr
From Proteopedia
(New page: 200px<br /><applet load="2bzr" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bzr, resolution 2.200Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:2bzr.jpg|left|200px]]<br /><applet load="2bzr" size=" | + | [[Image:2bzr.jpg|left|200px]]<br /><applet load="2bzr" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2bzr, resolution 2.200Å" /> | caption="2bzr, resolution 2.200Å" /> | ||
'''CRYSTAL STRUCTURE OF ACCD5 (RV3280), AN ACYL-COA CARBOXYLASE BETA-SUBUNIT FROM MYCOBACTERIUM TUBERCULOSIS'''<br /> | '''CRYSTAL STRUCTURE OF ACCD5 (RV3280), AN ACYL-COA CARBOXYLASE BETA-SUBUNIT FROM MYCOBACTERIUM TUBERCULOSIS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Mycobacterium tuberculosis contains multiple versions of the accA and accD | + | Mycobacterium tuberculosis contains multiple versions of the accA and accD genes that encode the alpha- and beta-subunits of at least three distinct multi-functional acyl-CoA carboxylase complexes. Because of its proposed involvement in pathogenic M. tuberculosis survival, the high-resolution crystal structure of the beta-subunit gene accD5 product has been determined and reveals a hexameric 356 kDa complex. Analysis of the active site properties of AccD5 and homology models of the other five M. tuberculosis AccD homologues reveals unexpected differences in their surface composition, providing a molecular rational key for a sorting mechanism governing correct acyl-CoA carboxylase holo complex assembly in M. tuberculosis. |
==About this Structure== | ==About this Structure== | ||
| - | 2BZR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/Propionyl-CoA_carboxylase Propionyl-CoA carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.3 6.4.1.3] Full crystallographic information is available from [http:// | + | 2BZR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Active as [http://en.wikipedia.org/wiki/Propionyl-CoA_carboxylase Propionyl-CoA carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.3 6.4.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Propionyl-CoA carboxylase]] | [[Category: Propionyl-CoA carboxylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Holton, S | + | [[Category: Holton, S J.]] |
| - | [[Category: XMTB, Mycobacterium | + | [[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]] |
[[Category: accase]] | [[Category: accase]] | ||
[[Category: fatty acid biosynthesis]] | [[Category: fatty acid biosynthesis]] | ||
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[[Category: xmtb]] | [[Category: xmtb]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:29 2008'' |
Revision as of 14:43, 21 February 2008
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CRYSTAL STRUCTURE OF ACCD5 (RV3280), AN ACYL-COA CARBOXYLASE BETA-SUBUNIT FROM MYCOBACTERIUM TUBERCULOSIS
Overview
Mycobacterium tuberculosis contains multiple versions of the accA and accD genes that encode the alpha- and beta-subunits of at least three distinct multi-functional acyl-CoA carboxylase complexes. Because of its proposed involvement in pathogenic M. tuberculosis survival, the high-resolution crystal structure of the beta-subunit gene accD5 product has been determined and reveals a hexameric 356 kDa complex. Analysis of the active site properties of AccD5 and homology models of the other five M. tuberculosis AccD homologues reveals unexpected differences in their surface composition, providing a molecular rational key for a sorting mechanism governing correct acyl-CoA carboxylase holo complex assembly in M. tuberculosis.
About this Structure
2BZR is a Single protein structure of sequence from Mycobacterium tuberculosis. Active as Propionyl-CoA carboxylase, with EC number 6.4.1.3 Full crystallographic information is available from OCA.
Reference
Structural diversity in the six-fold redundant set of acyl-CoA carboxyltransferases in Mycobacterium tuberculosis., Holton SJ, King-Scott S, Nasser Eddine A, Kaufmann SH, Wilmanns M, FEBS Lett. 2006 Dec 22;580(30):6898-902. Epub 2006 Nov 30. PMID:17157300
Page seeded by OCA on Thu Feb 21 16:43:29 2008
Categories: Mycobacterium tuberculosis | Propionyl-CoA carboxylase | Single protein | Holton, S J. | XMTB, Mycobacterium Tuberculosis Structural Proteomics Project. | Accase | Fatty acid biosynthesis | Ligase | Mycobacterium tuberculosis structural proteomics project | Structural genomics | Transferase | Xmtb
