2c0l
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Peroxisomes require the translocation of folded and functional target | + | Peroxisomes require the translocation of folded and functional target proteins of various sizes across the peroxisomal membrane. We have investigated the structure and function of the principal import receptor Pex5p, which recognizes targets bearing a C-terminal peroxisomal targeting signal type 1. Crystal structures of the receptor in the presence and absence of a peroxisomal target, sterol carrier protein 2, reveal major structural changes from an open, snail-like conformation into a closed, circular conformation. These changes are caused by a long loop C terminal to the 7-fold tetratricopeptide repeat segments. Mutations in residues of this loop lead to defects in peroxisomal import in human fibroblasts. The structure of the receptor/cargo complex demonstrates that the primary receptor-binding site of the cargo is structurally and topologically autonomous, enabling the cargo to retain its native structure and function. |
==Disease== | ==Disease== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Kursula, P.]] | [[Category: Kursula, P.]] | ||
| - | [[Category: Stanley, W | + | [[Category: Stanley, W A.]] |
[[Category: Wilmanns, M.]] | [[Category: Wilmanns, M.]] | ||
[[Category: alternative initiation]] | [[Category: alternative initiation]] | ||
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[[Category: zellweger syndrome]] | [[Category: zellweger syndrome]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:43:36 2008'' |
Revision as of 14:43, 21 February 2008
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TPR DOMAIN OF HUMAN PEX5P IN COMPLEX WITH HUMAN MSCP2
Contents |
Overview
Peroxisomes require the translocation of folded and functional target proteins of various sizes across the peroxisomal membrane. We have investigated the structure and function of the principal import receptor Pex5p, which recognizes targets bearing a C-terminal peroxisomal targeting signal type 1. Crystal structures of the receptor in the presence and absence of a peroxisomal target, sterol carrier protein 2, reveal major structural changes from an open, snail-like conformation into a closed, circular conformation. These changes are caused by a long loop C terminal to the 7-fold tetratricopeptide repeat segments. Mutations in residues of this loop lead to defects in peroxisomal import in human fibroblasts. The structure of the receptor/cargo complex demonstrates that the primary receptor-binding site of the cargo is structurally and topologically autonomous, enabling the cargo to retain its native structure and function.
Disease
Known diseases associated with this structure: Adrenoleukodystrophy, neonatal OMIM:[600414], Zellweger syndrome OMIM:[600414]
About this Structure
2C0L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p., Stanley WA, Filipp FV, Kursula P, Schuller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M, Mol Cell. 2006 Dec 8;24(5):653-63. PMID:17157249
Page seeded by OCA on Thu Feb 21 16:43:36 2008
Categories: Homo sapiens | Protein complex | Kursula, P. | Stanley, W A. | Wilmanns, M. | Alternative initiation | Disease mutation | Import receptor complex | Lipid transport | Lipid-binding | Mitochondrion | Peroxisome | Protein transport | Tpr repeat | Transit peptide | Transport | Transport protein/receptor complex | Zellweger syndrome
