9pai

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[[Image:9pai.png|left|200px]]
 
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{{STRUCTURE_9pai| PDB=9pai | SCENE= }}
{{STRUCTURE_9pai| PDB=9pai | SCENE= }}
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===CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1===
===CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1===
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{{ABSTRACT_PUBMED_7552714}}
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{{ABSTRACT_PUBMED_7552714}}
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==Disease==
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[[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
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==Function==
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[[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:007552714</ref><references group="xtra"/>
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<ref group="xtra">PMID:007552714</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aertgeerts, K.]]
[[Category: Aertgeerts, K.]]

Revision as of 16:57, 22 March 2013

Template:STRUCTURE 9pai

Contents

CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1

Template:ABSTRACT PUBMED 7552714

Disease

[PAI1_HUMAN] Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.

Function

[PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.[1]

About this Structure

9pai is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Aertgeerts K, De Bondt HL, De Ranter CJ, Declerck PJ. Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1. Nat Struct Biol. 1995 Oct;2(10):891-7. PMID:7552714
  1. ↑ Szabo R, Netzel-Arnett S, Hobson JP, Antalis TM, Bugge TH. Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem J. 2005 Aug 15;390(Pt 1):231-42. PMID:15853774 doi:BJ20050299

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OCA

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