2cum

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[[Image:2cum.png|left|200px]]
 
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{{STRUCTURE_2cum| PDB=2cum | SCENE= }}
{{STRUCTURE_2cum| PDB=2cum | SCENE= }}
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===The solution structure of the 33rd fibronectin type III domain of human Tenascin-X===
===The solution structure of the 33rd fibronectin type III domain of human Tenascin-X===
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==Disease==
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[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[http://omim.org/entry/606408 606408]]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
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==Function==
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[[http://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN]] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>
==About this Structure==
==About this Structure==
[[2cum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUM OCA].
[[2cum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUM OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inoue, M.]]
[[Category: Inoue, M.]]

Revision as of 09:23, 24 March 2013

Template:STRUCTURE 2cum

Contents

The solution structure of the 33rd fibronectin type III domain of human Tenascin-X

Disease

[TENX_HUMAN] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:606408]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.

Function

[TENX_HUMAN] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.[1]

About this Structure

2cum is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  1. ↑ Egging D, van den Berkmortel F, Taylor G, Bristow J, Schalkwijk J. Interactions of human tenascin-X domains with dermal extracellular matrix molecules. Arch Dermatol Res. 2007 Jan;298(8):389-96. Epub 2006 Oct 11. PMID:17033827 doi:10.1007/s00403-006-0706-9

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