3crd

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[[Image:3crd.png|left|200px]]
 
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{{STRUCTURE_3crd| PDB=3crd | SCENE= }}
{{STRUCTURE_3crd| PDB=3crd | SCENE= }}
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===NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES===
===NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES===
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{{ABSTRACT_PUBMED_9695946}}
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{{ABSTRACT_PUBMED_9695946}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CRADD_HUMAN CRADD_HUMAN]] Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34) [MIM:[http://omim.org/entry/614499 614499]]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.<ref>PMID:22279524</ref>
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==Function==
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[[http://www.uniprot.org/uniprot/CRADD_HUMAN CRADD_HUMAN]] Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:009695946</ref><references group="xtra"/>
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<ref group="xtra">PMID:009695946</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chou, J J.]]
[[Category: Chou, J J.]]

Revision as of 09:47, 24 March 2013

Template:STRUCTURE 3crd

Contents

NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES

Template:ABSTRACT PUBMED 9695946

Disease

[CRADD_HUMAN] Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34) [MIM:614499]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.[1]

Function

[CRADD_HUMAN] Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.

About this Structure

3crd is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Chou JJ, Matsuo H, Duan H, Wagner G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell. 1998 Jul 24;94(2):171-80. PMID:9695946
  1. ↑ Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA. Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012;7(1):e28936. doi: 10.1371/journal.pone.0028936. Epub 2012 Jan 17. PMID:22279524 doi:10.1371/journal.pone.0028936

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