1h02

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[[Image:1h02.png|left|200px]]
 
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{{STRUCTURE_1h02| PDB=1h02 | SCENE= }}
{{STRUCTURE_1h02| PDB=1h02 | SCENE= }}
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===HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA===
===HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA===
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{{ABSTRACT_PUBMED_12135360}}
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{{ABSTRACT_PUBMED_12135360}}
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==Disease==
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[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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==Function==
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[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012135360</ref><references group="xtra"/>
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<ref group="xtra">PMID:012135360</ref><references group="xtra"/><references/>
[[Category: Growth Hormone]]
[[Category: Growth Hormone]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 09:50, 24 March 2013

Template:STRUCTURE 1h02

Contents

HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA

Template:ABSTRACT PUBMED 12135360

Disease

[IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

Function

[IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.[1]

About this Structure

1h02 is a 1 chain structure with sequence from Homo sapiens. The April 2004 RCSB PDB Molecule of the Month feature on Growth Hormone by Shuchismita Dutta and David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_4. Full crystallographic information is available from OCA.

See Also

Reference

  • Brzozowski AM, Dodson EJ, Dodson GG, Murshudov GN, Verma C, Turkenburg JP, de Bree FM, Dauter Z. Structural origins of the functional divergence of human insulin-like growth factor-I and insulin. Biochemistry. 2002 Jul 30;41(30):9389-97. PMID:12135360
  1. ↑ Zoidis E, Ghirlanda-Keller C, Schmid C. Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I. Mol Cell Biochem. 2011 Feb;348(1-2):33-42. doi: 10.1007/s11010-010-0634-z. Epub, 2010 Nov 13. PMID:21076856 doi:10.1007/s11010-010-0634-z

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