4hqu
From Proteopedia
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{{STRUCTURE_4hqu| PDB=4hqu | SCENE= }} | {{STRUCTURE_4hqu| PDB=4hqu | SCENE= }} | ||
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===Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)=== | ===Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)=== | ||
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{{ABSTRACT_PUBMED_23139410}} | {{ABSTRACT_PUBMED_23139410}} | ||
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| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN]] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref> | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN]] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[4hqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQU OCA]. | [[4hqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQU OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Davies, D R.]] | [[Category: Davies, D R.]] | ||
Revision as of 10:05, 24 March 2013
Contents |
Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)
Template:ABSTRACT PUBMED 23139410
Disease
[PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.[1]
Function
[PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
About this Structure
4hqu is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
