1k78
From Proteopedia
(Difference between revisions)
m (Protected "1k78" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1k78.png|left|200px]] | ||
| - | |||
{{STRUCTURE_1k78| PDB=1k78 | SCENE= }} | {{STRUCTURE_1k78| PDB=1k78 | SCENE= }} | ||
| - | |||
===Pax5(1-149)+Ets-1(331-440)+DNA=== | ===Pax5(1-149)+Ets-1(331-440)+DNA=== | ||
| + | {{ABSTRACT_PUBMED_11779502}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/PAX5_HUMAN PAX5_HUMAN]] Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6. | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ETS1_MOUSE ETS1_MOUSE]] Transcription factor. [[http://www.uniprot.org/uniprot/PAX5_HUMAN PAX5_HUMAN]] May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene. | ||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 13: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:011779502</ref><references group="xtra"/> | + | <ref group="xtra">PMID:011779502</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 10:39, 24 March 2013
Contents |
Pax5(1-149)+Ets-1(331-440)+DNA
Template:ABSTRACT PUBMED 11779502
Disease
[PAX5_HUMAN] Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
Function
[ETS1_MOUSE] Transcription factor. [PAX5_HUMAN] May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
About this Structure
1k78 is a 9 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
- Garvie CW, Hagman J, Wolberger C. Structural studies of Ets-1/Pax5 complex formation on DNA. Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502
