1qox
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(New page: 200px<br /> <applet load="1qox" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qox, resolution 2.7Å" /> '''BETA-GLUCOSIDASE FRO...)
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Revision as of 14:21, 29 October 2007
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BETA-GLUCOSIDASE FROM BACILLUS CIRCULANS SP. ALKALOPHILUS
Overview
Family 1 of glycosyl hydrolases is a large and biologically important, group of enzymes. A new three-dimensional structure of this family, beta-glucosidase from Bacillus circulans sp. alkalophilus is reported, here. This is the first structure of beta-glucosidase from an alkaliphilic, organism. The model was determined by the molecular replacement method and, refined to a resolution of 2.7 A. The quaternary structure of B. circulans, sp. alkalophilus beta-glucosidase is an octamer and subunits of the, octamer show a similar (beta/alpha)(8) barrel fold to that previously, reported for other family 1 enzymes. The crystal structure suggested that, Cys169 in the active site is substituted. The Cys169 is located near the, putative acid/base catalyst Glu166 and it may contribute to the high pH, ... [(full description)]
About this Structure
1QOX is a [Single protein] structure of sequence from [Bacillus circulans]. Active as [[1]], with EC number [3.2.1.21]. Full crystallographic information is available from [OCA].
Reference
The crystal structure of beta-glucosidase from Bacillus circulans sp. alkalophilus: ability to form long polymeric assemblies., Hakulinen N, Paavilainen S, Korpela T, Rouvinen J, J Struct Biol. 2000 Feb;129(1):69-79. PMID:10675298
Page seeded by OCA on Mon Oct 29 16:26:14 2007
