1sac

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m (Protected "1sac" [edit=sysop:move=sysop])
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[[Image:1sac.png|left|200px]]
 
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{{STRUCTURE_1sac| PDB=1sac | SCENE= }}
{{STRUCTURE_1sac| PDB=1sac | SCENE= }}
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===THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT===
===THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT===
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{{ABSTRACT_PUBMED_8114934}}
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{{ABSTRACT_PUBMED_8114934}}
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==Disease==
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[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
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==Function==
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[[http://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN]] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:008114934</ref><ref group="xtra">PMID:011170211</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/>
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<ref group="xtra">PMID:008114934</ref><ref group="xtra">PMID:011170211</ref><ref group="xtra">PMID:011880627</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blundell, T L.]]
[[Category: Blundell, T L.]]

Revision as of 11:21, 24 March 2013

Template:STRUCTURE 1sac

Contents

THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT

Template:ABSTRACT PUBMED 8114934

Disease

[SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Function

[SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

About this Structure

1sac is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP. Structure of pentameric human serum amyloid P component. Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934 doi:http://dx.doi.org/10.1038/367338a0
  • Thomas A, Bouffioux O, Geeurickx D, Brasseur R. Pex, analytical tools for PDB files. I. GF-Pex: basic file to describe a protein. Proteins. 2001 Apr 1;43(1):28-36. PMID:11170211
  • Richardson JS, Richardson DC. Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2754-9. PMID:11880627 doi:10.1073/pnas.052706099

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OCA

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