2z5y

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[[Image:2z5y.png|left|200px]]
 
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{{STRUCTURE_2z5y| PDB=2z5y | SCENE= }}
{{STRUCTURE_2z5y| PDB=2z5y | SCENE= }}
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===Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine===
===Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine===
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{{ABSTRACT_PUBMED_18391214}}
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{{ABSTRACT_PUBMED_18391214}}
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==Disease==
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[[http://www.uniprot.org/uniprot/AOFA_HUMAN AOFA_HUMAN]] Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:[http://omim.org/entry/300615 300615]]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
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==Function==
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[[http://www.uniprot.org/uniprot/AOFA_HUMAN AOFA_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:018391214</ref><references group="xtra"/>
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<ref group="xtra">PMID:018391214</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Monoamine oxidase]]
[[Category: Monoamine oxidase]]

Revision as of 11:25, 24 March 2013

Template:STRUCTURE 2z5y

Contents

Crystal Structure of Human Monoamine Oxidase A (G110A) with Harmine

Template:ABSTRACT PUBMED 18391214

Disease

[AOFA_HUMAN] Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.

Function

[AOFA_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

About this Structure

2z5y is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Son SY, Ma J, Kondou Y, Yoshimura M, Yamashita E, Tsukihara T. Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5739-44. Epub 2008 Apr 7. PMID:18391214

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OCA

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