2ain
From Proteopedia
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{{STRUCTURE_2ain| PDB=2ain | SCENE= }} | {{STRUCTURE_2ain| PDB=2ain | SCENE= }} | ||
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===Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein=== | ===Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein=== | ||
| + | {{ABSTRACT_PUBMED_17473018}} | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. [[http://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN]] Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). | ||
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| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/AFAD_HUMAN AFAD_HUMAN]] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. [[http://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN]] GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.<ref>PMID:1903516</ref><ref>PMID:1657398</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:017473018</ref><references group="xtra"/> | + | <ref group="xtra">PMID:017473018</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, Q.]] | [[Category: Chen, Q.]] | ||
Revision as of 11:39, 24 March 2013
Contents |
Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein
Template:ABSTRACT PUBMED 17473018
Disease
[AFAD_HUMAN] Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein. [BCR_HUMAN] Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
Function
[AFAD_HUMAN] Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. [BCR_HUMAN] GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.[1][2]
About this Structure
2ain is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Chen Q, Niu X, Xu Y, Wu J, Shi Y. Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex. Protein Sci. 2007 Jun;16(6):1053-62. Epub 2007 May 1. PMID:17473018 doi:10.1110/ps.062440607
- ↑ Diekmann D, Brill S, Garrett MD, Totty N, Hsuan J, Monfries C, Hall C, Lim L, Hall A. Bcr encodes a GTPase-activating protein for p21rac. Nature. 1991 May 30;351(6325):400-2. PMID:1903516 doi:http://dx.doi.org/10.1038/351400a0
- ↑ Maru Y, Witte ON. The BCR gene encodes a novel serine/threonine kinase activity within a single exon. Cell. 1991 Nov 1;67(3):459-68. PMID:1657398
